Histamine Intolerance
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Histamine intolerance (HIT) occurs when the body fails to balance histamine intake and breakdown, leading to excess histamine and systemic symptoms. While histamine is essential for gut, brain, nervous system, and immune function, inefficient clearance can cause HIT, which shares symptoms with MCAS but is distinct.
Recovery involves dietary changes, targeted supplements (like DAO), and supporting histamine clearance pathways. A low-histamine or low-FODMAP diet can help manage symptoms, which may be intermittent or persistent, worsening as histamine accumulates.
Nervous System Dysregulation & Histamine Intolerance
The nervous system directly influences histamine release, with stress and nerve signals triggering mast cells. In those with impaired histamine metabolism, this leads to headaches, fatigue, anxiety, flushing, and digestive issues.
An impaired/dysregulated autonomic nervous system can further disrupt histamine levels, as histamine also acts as a neurotransmitter, linking brain activity to conditions like MCAS, POTS, and Chronic Fatigue Syndrome. Managing stress, following a low-histamine diet, and balancing hormones are key to reducing symptoms and restoring health.
The Gut & Histamine Intolerance
Gut imbalances like SIBO, dysbiosis, leaky gut, and food sensitivities can trigger or worsen histamine intolerance, creating a vicious cycle. Mast cells, which release histamine, are influenced by gut inflammation, increasing histamine sensitivity. Imbalanced gut bacteria, especially those that produce histamine, further exacerbate symptoms, making gut health essential for managing HIT.
Healing the gut is key to managing histamine intolerance and mast cell issues. A low-histamine or low-FODMAP diet can help, especially with SIBO or IBS. Prioritize fresh, nutrient-dense foods while avoiding alcohol and fermented foods, which can worsen symptoms. The SIGHI food list is a helpful guide.
Diets For Histamine Intolerance
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Low Histamine Foods, Doesnt't Mean They Are Automatically Low FODMAP and Vice Versa. You Will Need To Cross-Reference, Dependent On Your Specific Issues . A SIGHI Chart Can Be Very Helpful As Well!
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Supplements & Medicines For Histamine Intolerance
Recovering From Histamine Intolerance
Supplements to Aid in Histamine Intolerance
Supplements like natural antihistamines and gut-supportive options can play a role in managing symptoms and improving overall health. These include:
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Our natural antihistamines help reduce histamine levels and inflammation.
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We have enzymes to support the breakdown of histamine in the body.
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Specific probiotics that are formulated to restore balance in the gut microbiome and not create flares.
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HCL helps break down food, absorb nutrients, and kill bacteria.
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Always consult your physician before starting any supplements to ensure they do not pose any risks or interact with medications you are currently taking.
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Medicines for Histamine Intolerance
Various medications help manage histamine intolerance by targeting specific symptoms:
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H1 Antihistamines (cetirizine, loratadine, fexofenadine) – Relieve allergy symptoms like sneezing, itching, and runny nose.
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H2 Antihistamines (famotidine, ranitidine) – Reduce digestive issues like acid reflux and heartburn.
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Corticosteroids – Decrease inflammation from histamine reactions, often used in asthma treatment.
These medications provide targeted symptom relief for histamine intolerance.
Additional Treatment Options
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Mast Cell Stabilizers – Prevent histamine release, reducing allergic and inflammatory reactions.
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Flavonoids – Natural compounds that help regulate histamine levels.
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Exercise – 30-60 minutes daily supports overall health and symptom reduction.
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Relaxation Techniques – Deep breathing, muscle relaxation, and social time help manage stress and regulate the nervous system.
